1,2-Wittig rearrangement

What is 1,2-Wittig rearrangement?

The 1,2-Wittig rearrangement is a chemical reaction in which alkyl lithiums react with ethers to form alcohols through a [1,2]-shift.

1,2-Wittig rearrangement
1,2-Wittig rearrangement

References

  • Wittig, G. and Löhmann, L. (1942), Übe die kationtrope Isomerisation gewisser Benzyläther bei Einwirkung von Phenyl-lithium. [Exercise the cationtropic isomerization of certain benzyl ethers on exposure to phenyl lithium.] Justus Liebigs Ann. Chem., 550: 260-268. https://doi.org/10.1002/jlac.19425500117
  • Wittig, G. Ergebnisse und Probleme der organischen Anionochemie. [Results and problems of organic anionochemistryExperientia 14, 389–395 (1958). DOI: 10.1007/BF02160421
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