Allan-Robinson condensation

What is Allan-Robinson condensation?

The first documentation of the reaction was made by Allan and Robinson in 1924. The synthesis of flavones or isoflavones derivatives is achieved through the condensation of o-hydroxyaryl ketones with an anhydride of aromatic acid in the presence of the corresponding acid’s sodium salt in the anhydride. This reaction is commonly known as the Allan-Robinson condensation, also referred to as Allan-Robinson’s flavone synthesis, Allan-Robinson reaction, or Allan-Robinson synthesis.

Allan-Robinson condensation - Allan-Robinson's flavone synthesis - Allan-Robinson reaction - Allan-Robinson synthesis
Allan-Robinson condensation

It has been widely used for synthesizing structurally diverse flavonoids and isoflavones.

References

Allan, J. and Robinson, R., “CCXC.—An accessible derivative of chromonolJ. Chem. Soc., Trans., 1924, 125, 2192-2195
DOI: 10.1039/CT9242502192

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