Allan-Robinson condensation

What is Allan-Robinson condensation?

The first documentation of the reaction was made by Allan and Robinson in 1924. The synthesis of flavones or isoflavones derivatives is achieved through the condensation of o-hydroxyaryl ketones with an anhydride of aromatic acid in the presence of the corresponding acid’s sodium salt in the anhydride. This reaction is commonly known as the Allan-Robinson condensation, also referred to as Allan-Robinson’s flavone synthesis, Allan-Robinson reaction, or Allan-Robinson synthesis.

Allan-Robinson condensation - Allan-Robinson's flavone synthesis - Allan-Robinson reaction - Allan-Robinson synthesis
Allan-Robinson condensation

It has been widely used for synthesizing structurally diverse flavonoids and isoflavones.


Allan, J. and Robinson, R., “CCXC.—An accessible derivative of chromonolJ. Chem. Soc., Trans., 1924, 125, 2192-2195
DOI: 10.1039/CT9242502192