Angeli-Remini reaction

What is Angeli-Remini reaction?

In 1896, Angeli reported the discovery of a reaction that prepares hydroxamic acids using aldehyde and benzosulfohydroxamic acid. This reaction is commonly known as the Angeli-Remini reaction. Hydroxamic acids are an essential class of reagents with diverse applications in organic, inorganic, and pharmaceutical chemistry. They are utilized as antibiotics, inhibitors, and potent metal ion-chelators.

Angeli-Remini reaction - hydroxamic acids
Angeli-Remini reaction

Despite the significance of the Angeli-Remini reaction, other methods have been developed to synthesize various types of hydroxamic acids.


Angeli A., Gazz. Chim. Ital., 1896, 26, II, 17