Auwers flavone synthesis

What is Auwers flavone synthesis?

The Auwers flavone synthesis, also known as the Auwers synthesis, is a method used to expand coumarones into flavonols. This is achieved by treating 2-bromo-2-(α-bromobenzyl)coumarones with alcoholic alkali, which leads to the formation of flavonols.

Auwers flavone synthesis - Auwers synthesis
Auwers flavone synthesis

References

  • Auwers, K. and Müller, K. (1908), Umwandlung von Benzal-cumaranonen in Flavonole. [Conversion of benzal-coumaranones to flavonols.] Ber. Dtsch. Chem. Ges., 41: 4233-4241. https://doi.org/10.1002/cber.190804103137
  • v. Auwers, K. and Pohl, P. (1915), Eine Synthese des Fisetins. [A synthesis of fisetin.] Ber. Dtsch. Chem. Ges., 48: 85-90. https://doi.org/10.1002/cber.19150480114
  • v. Auwers, K. (1916), Zur Bildung von Flavonolen aus Benzal-cumaranonen. [For the formation of flavonols from benzal-coumaranones.] Ber. Dtsch. Chem. Ges., 49: 809-819. https://doi.org/10.1002/cber.19160490188
  • Auwers, K.V. and Pohl, P. (1914), Über die Umwandlung von Benzalcumaranonen in Flavonole. [On the conversion of benzalcoumaranones to flavonols.] Justus Liebigs Ann. Chem., 405: 243-294. https://doi.org/10.1002/jlac.19144050302

Shares