Bailey peptide synthesis

What is Bailey peptide synthesis?

Numerous methods have been developed to synthesize peptides, including the use of N-carboxyanhydrides (NCAs). The most effective application of the NCA method in peptide synthesis is the one developed by Bailey in 1949, in which amino acids and peptide esters react with NCAs at low temperatures in organic solvents. This reaction is known as the Bailey peptide synthesis orΒ Bailey peptide ester synthesis.

Bailey peptide synthesis
Bailey peptide synthesis

This method has a significant advantage in that it rapidly acylates an amino acid, with the reaction completing in just a few minutes to a few hours, resulting in a peptide with a very high yield. Furthermore, the reaction between NCAs and amino acids or peptides can be accomplished without protecting the functional groups of the amino acids or peptides, thereby directly producing a free peptide from an amino acid. Although a by-product sometimes occurs, N-substituted NCAs have been developed to allow for easy removal of the formed by-product through conventional washing of the product with an acid or base.

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