Bamberger benzotriazine synthesis

What is Bamberger benzotriazine synthesis?

Eugen Bamberger reported the classic Bamberger benzotriazine synthesis in 1892, which is an organic synthesis that involves the conversion of a hydrazone and aryldiazoamine salts into a benzotriazine.

Bamberger benzotriazine synthesis
Bamberger benzotriazine synthesis

To carry out the Bamberger benzotriazine synthesis, an aryl diazonium salt is generated through the reaction of the corresponding aniline with sodium nitrite and hydrochloric acid, while the hydrazone of pyruvic acid serves as the other reactant. The azo intermediate formed in the second step is then converted to benzotriazine in the third step using sulfuric acid in acetic acid.

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