Baumgarten α-amino ketone synthesis

What is Baumgarten α-amino ketone synthesis?

The synthesis of α-amino ketones through the rearrangement of N,N-dichloro-sec-alkylamines using sodium methoxide was first reported by Baumgarten in 1954. These N,N-dichloro-sec-alkylamines are obtained by chlorination of sec-alkylamines with chlorine in the so-called Baumgarten α-amino ketone synthesis.

Baumgarten α-amino ketone synthesis -  general reaction scheme
Baumgarten α-amino ketone synthesis

References

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