Blaise ketone synthesis

What is Blaise ketone synthesis?

The Blaise ketone synthesis, also known as Blaise-Maire reaction, is a method for the preparation of ketones by reacting acid halides with organozinc compounds. The reaction can also be used to obtain β-hydroxy ketones from β-hydroxy carbonyl chlorides, which can be further converted into α,β-unsaturated ketones. The reaction is typically carried out under reflux conditions in dilute sulfuric acid (H2SO4).

Blaise ketone synthesis
Blaise ketone synthesis


  • E.E. Blaise, A. Koehler, Bull. Soc. Chim. 7, 215 (1910)
  • E.E. Blaise, M. Maire, Compt. Rend. 145, 73 (1907)
  • E.E. Blaise, Bull. Soc. Chim. 9, 1 (1911)