Blaise reaction

What is Blaise reaction?

The Blaise reaction is a method for synthesizing β-oxoesters. It involves the reaction of α-bromocarboxylic esters with zinc in the presence of nitriles. The intermediate organozinc compound formed in this reaction reacts with the nitrile, and the resulting complex is then hydrolyzed using 30 % potassium hydroxide. This reaction was first described by French chemist Edmond Blaise in 1901.

Blaise reaction
Blaise reaction

Mechanism of reaction

The Blaise reaction follows a mechanism involving the nucleophilic addition of zinc enolate to nitrile, which is similar to the mechanism of the Reformatsky reaction.


E. E. Blaise, Compt. Rend. Acad. Sci. Paris 132, 478 (1901)