Conia reaction

What is Conia reaction?

The Conia reaction is a chemical process that involves the intramolecular ene reaction of unsaturated ketones. In this reaction, the carbonyl functionality of the ketone serves as the ene component through its tautomer, while the olefinic moiety serves as the enophile.

Conia reaction - intramolecular ene reaction
Conia reaction


Francis Rouessac, Pierre Beslin, Jean-Marie Conia,
La cyclisation thermique des cetones cycliques εζ-ethyleniques. Voie d’acces aux cetones polycycliques, [Thermal cyclization of cyclic εζ-ethylenic cetones. Access route to polycyclic cetones] Tetrahedron Letters, 6 (37) 3319-3323 (1965)
DOI: 10.1016/S0040-4039(01)89202-9.