Darzens-Nenitzescu synthesis of ketones

What is Darzens-Nenitzescu synthesis of ketones?

The Darzens-Nenitzescu synthesis of ketones is a chemical process that involves the acylation of olefins using acid chlorides or anhydrides that are catalyzed by Lewis acids to produce ketones. When this synthesis is carried out in the presence of a saturated hydrocarbon, the resulting product is a saturated ketone.

Darzens-Nenitzescu synthesis ketones
Darzens-Nenitzescu synthesis of ketones

References

  • G. Darzens, Compt. Rend. 150, 707 (1910)
  • Nenitzescu, C.D. and Cantuniari, J.P. (1934), Durch Aluminiumchlorid katalysierte Reaktionen. IX. Mitteilung. Über den Mechanismus der Ketonbildung aus Cycloparaffinen und Acetylchlorid in Gegenwart von Aluminiumchlorid. [Reactions catalyzed by aluminum chloride. IX. Communication. On the mechanism of ketone formation from cycloparaffins and acetyl chloride in the presence of aluminum chloride.] Justus Liebigs Ann. Chem., 510: 269-279. https://doi.org/10.1002/jlac.19345100118
  • Nenitzescu, C.D. and Ciorănescu, E. (1936), Durch Aluminiumchlorid katalysierte Reaktionen, XV. Mitteil.: Über die Darstellung gesättigter Ketone durch Anlagerung von Säurechloriden an Olefine und Hydrierung mittels Aluminium-chlorids. [Reactions catalyzed by aluminum chloride, XV. communication..: On the preparation of saturated ketones by addition of acid chlorides to olefins and hydrogenation by means of aluminum chloride.] Ber. dtsch. Chem. Ges. A/B, 69: 1820-1823. https://doi.org/10.1002/cber.19360690804
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