Doering-LaFlamme allene synthesis

What is Doering-LaFlamme allene synthesis?

The Doering-LaFlamme synthesis is a chemical process that involves treating an olefin with bromoform and an alkoxide. This results in the formation of 1,1-dibromocyclopropane, which can then react with an active metal to produce an allene.

Doering-LaFlamme allene synthesis
Doering-LaFlamme allene synthesis

Allenes can be obtained through a two-step process. Firstly, dibromocarbene is added to an olefin, followed by the reaction of the resulting substituted 1,1-dibromocyclopropane with either magnesium or sodium. This sequence results in the insertion of a single carbon atom between the original double bond, thereby increasing the carbon chain length by one atom. This method is considered innovative for its ability to achieve such a structural change.

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