Einhorn-Brunner reaction

What is Einhorn-Brunner reaction?

The Einhorn-Brunner reaction is a chemical process that involves the formation of substituted 1,2,4-triazoles through the acid-catalyzed condensation of diacylamines with hydrazines or semicarbazides. This reaction is named after the German chemists Alfred Einhorn and Karl Brunner, who discovered it.

Einhorn-Brunner reaction
Einhorn-Brunner reaction

References

  • Einhorn, A., Bischkopff, E., Szelinski, B., Schupp, G., Spröngerts, E., Ladisch, C. and Mauermayer, T. (1905), Ueber die N-Methylolverbindungen der Säureamide [Erste Abhandlung.]. Justus Liebigs Ann. Chem., 343: 207-305. https://doi.org/10.1002/jlac.19053430207
  • Brunner, K. (1914), Eine neue Darstellungsweise von sekundären Säureamiden. Ber. Dtsch. Chem. Ges., 47: 2671-2680. https://doi.org/10.1002/cber.19140470351
  • Brunner, K. Monatsh. 36, 509 (1915)
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