Electrophilic Aromatic Substitution Named Reactions (SEAr)

What is Electrophilic Aromatic Substitution Named Reactions (SEAr)?

Electrophilic Aromatic Substitution (SEAr) is a type of chemical reaction that occurs when an electrophile, or electron-deficient species, substitutes an atom or group of atoms in an aromatic ring. The electrophile attacks the electron-rich aromatic ring, leading to the formation of a new bond and the substitution of the original atoms or groups..

There are several important named reactions that fall under the category of SEAr. One of the most well-known is the Friedel-Crafts reaction, in which an alkyl or acyl halide is reacted with an aromatic compound in the presence of a Lewis acid catalyst, such as aluminum chloride. This leads to the substitution of a halogen atom with an alkyl or acyl group..

Another important named reaction is the Sandmeyer reaction, in which an aryl diazonium salt is reacted with a copper or silver salt to form an aryl halide. This reaction is useful for the synthesis of aryl halides, which are important intermediates in the synthesis of many compounds..

Yet another named reaction is the Fries rearrangement which is a rearrangement reaction of an ester of an aromatic carboxylic acid, in which the ester group migrates to the ortho or para position. This reaction proceeds through the formation of a intermediate acylium ion..

The SEAr reactions are important in the synthesis of a wide range of compounds, including drugs, dyes, and other organic molecules. These reactions are also used in the production of many industrial chemicals and in the development of new materials..

Overall, SEAr reactions are a crucial tool for organic chemists and have a broad range of applications in the synthesis of useful compounds. It’s important to have a good understanding of the different named reactions and their specific reactivity and mechanism for a successful outcome in organic synthesis..

Within the named organic reactions, we can group those that take place by means of an electrophilic aromatic substitution reaction (SEAr). The following is a list of the best known ones:

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