Ene reaction

What is ene reaction?

The Ene reaction, which is also known as the Alder-ene reaction, involves the addition of an alkene that has an allylic hydrogen (ene) to a compound that contains a multiple bond (enophile). This chemical process results in the formation of a new bond between two unsaturated termini, with an allylic shift of the ene double bond and transfer of the allylic hydrogen to the enophile. The mechanism of this reaction is related to that of the Diels-Alder reaction.

Ene Reaction (Alder-Ene reaction)


Alder, K., Pascher, F. and Schmitz, A. (1943), Über die Anlagerung von Maleinsäure-anhydrid und Azodicarbonsäure-ester an einfach ungesättigte Koh an einfach ungesättigte Kohlenwasserstoffe. Zur Kenntnis von Substitutionsvorgängen in der Allyl-Stellung. [On the addition of maleic anhydride and azodicarboxylic ester to monounsaturated coh to monounsaturated hydrocarbons. On the knowledge of substitution processes in the allyl position.] Ber. dtsch. Chem. Ges. A/B, 76: 27-53. https://doi.org/10.1002/cber.19430760105