Erlenmeyer-Plöchl azlactone and amino acid synthesis

What is Erlenmeyer-Plöchl azlactone and amino acid synthesis?

The Erlenmeyer-Plöchl azlactone and amino acid synthesis is a chemical process used to create azlactones through the intramolecular condensation of acylglycines in the presence of acetic anhydride.

Erlenmeyer-Plochl azlactone amino acid synthesis - general reaction scheme
Erlenmeyer-Plöchl azlactone and amino acid synthesis

These azlactones can then be reacted with carbonyl compounds, followed by hydrolysis, to produce unsaturated α-acylamino acids. By reducing the unsaturated α-acylamino acids, the corresponding amino acids can be obtained. Alternatively, if the azlactones undergo drastic hydrolysis, the resulting product will be the α-oxo acid.

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