Fürstner indole synthesis

What is Fürstner indole synthesis?

The Fürstner indole synthesis involves using an intramolecular McMurry coupling to prepare indoles. This process involves the reduction of a titanium cation to zerovalent titanium by zinc. Additionally, the reaction can be made catalytic.

Fürstner indole synthesis - general reaction scheme
Fürstner indole synthesis

The process involves a Ti-induced reductive cyclization of oxo amides. Fürstner indole synthesis is particularly well-suited for the production of natural products, ranging the yield from 57 % to 92 %.

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