Gallagher-Hollander degradation

What is Gallagher-Hollander degradation?

The Gallagher-Hollander degradation method involves the elimination of pyruvic acid, which is a type of linear aliphatic carboxylic acid. This results in the formation of a new acid molecule that has two fewer carbon atoms than the original.

By removing pyruvic acid through this process, the resulting acid molecule becomes shorter and may have different properties than the original compound. This method can be useful in various chemical applications where a shorter or modified acid molecule is desired.

Gallagher-Hollander degradation
Gallagher-Hollander degradation


V.P. Hollander and T.F. Gallagher, “Partial Synthesis of Compounds Related to Adrenal Cortical Hormones: Vii. Degradation of the Side Chain of Cholanic Acid” Journal of Biological Chemistry 162 (3), 549-553 (1946)
DOI: 10.1016/S0021-9258(17)41399-8.