Hammick reaction

What is Hammick reaction?

The Hammick reaction, also referred to as picolinic acid decarboxylation, is a chemical reaction that involves the decarboxylation of α-picolinic or related acids in the presence of carbonyl compounds. This reaction results in the formation of a new carbon-carbon bond.

Hammick reaction - picolinic acid decarboxylation
Hammick reaction


P. Dyson, D. L. Hammick, “Experiments on the mechanism of decarboxylation. Part I. Decomposition of quinaldinic and isoquinaldinic acids in the presence of compounds containing carbonyl groupsJ. Chem. Soc., 1937, 1724-1725