Hass-Bender oxidation

What is Hass-Bender oxidation?

In 1949, Hass and Bender first described a chemical reaction that involves treating substituted benzyl halides with sodium nitropropane salt (sodium propane-nitronate) to synthesize aromatic aldehydes.

Hass-Bender oxidation - general reaction scheme - Hass-Bender reaction
Hass-Bender oxidation

Hass-Bender oxidation is commonly known as the Hass-Bender reaction, and it can also occur on aromatic polycyclic compounds.


The Reaction of Benzyl Halides with the Sodium Salt of 2-Nitropropane.1 A General Synthesis of Substituted Benzaldehydes
H. B. Hass and Myron L. Bender
Journal of the American Chemical Society 1949 71 (5), 1767-1769
DOI: 10.1021/ja01173a066