Haworth methylation

What is Haworth methylation?

The Haworth methylation is a chemical reaction used to prepare methylated methyl glycosides from monosaccharides, using dimethyl sulfate (CH3O)2SO2 and 30 % sodium hydroxide NaOH.

Haworth methylation
Haworth methylation

The Haworth methylation involves the methylation of the glycosidic hydroxyl group, which can be subsequently hydrolyzed with acid to yield the free methylated sugar.


W. N. Haworth, “III.—A new method of preparing alkylated sugarsJ. Chem. Soc., Trans., 1915, 107, 8-16
DOI: 10.1039/CT9150700008