Hinsberg thiophene synthesis

What is Hinsberg thiophene synthesis?

The Hinsberg thiophene synthesis is a chemical process used to create derivatives of thiophene carboxylic acids. This is achieved through the reaction of α-diketones with dialkyl thiodiacetates.

Hinsberg thiophene synthesis - general reaction scheme
Hinsberg thiophene synthesis

References

Hinsberg, O. (1910), Synthetische Versuche mit Thiodiglykolsäureester. [Synthetic tests with thiodiglycolic acid ester] Ber. Dtsch. Chem. Ges., 43: 901-906. https://doi.org/10.1002/cber.191004301153

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