Hofmann isonitrile synthesis

What is Hofmann isonitrile synthesis?

The Hofmann isonitrile synthesis, also referred to as the carbylamine reaction, is a chemical process used to create isonitriles. This is achieved through the reaction of primary amines with chloroform in the presence of an alkali. One key characteristic of this reaction is the strong odor of the isocyanide, which serves as a diagnostic test for the presence of a primary amine.

Hofmann isonitrile synthesis carbylamine reaction
Hofmann isonitrile synthesis (carbylamine reaction)

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