Japp-Klingemann reaction

What is Japp-Klingemann reaction?

The Japp-Klingemann reaction involves the combination of aryldiazonium salts with active methylene compounds to form hydrazones. The activating group in at least one of the compounds typically consists of acyl or carboxyl, and it is usually cleaved during the reaction process.

Japp-Klingemann reaction
Japp-Klingemann reaction

References

  • Japp, F.R. and Klingemann, F. (1887), Ueber Benzolazo- und Benzolhydrazofettsäuren. [On benzene azo and benzene hydrazo fatty acids.] Ber. Dtsch. Chem. Ges., 20: 2942-2944. https://doi.org/10.1002/cber.188702002165
  • Japp, F.R. and Klingemann, F. (1887), Zur Kenntniss der Benzolazo- und Benzolhydrazopropionsäuren. [On the knowledge of benzene azo and benzene hydrazopropionic acids.] Ber. Dtsch. Chem. Ges., 20: 3284-3286. https://doi.org/10.1002/cber.188702002234
  • Japp, F.R. and Klingemann, F. (1887), Ueber sogenannte »gemischte Azoverbindungen«. [On so-called “mixed azo compounds”.] Ber. Dtsch. Chem. Ges., 20: 3398-3401. https://doi.org/10.1002/cber.188702002268
  • Japp, F.R. and Klingemann, F. (1888), Ueber die Constitution einiger sogenannten gemischten Azoverbindungen. [On the constitution of some so-called mixed azo compounds.] Justus Liebigs Ann. Chem., 247: 190-225. https://doi.org/10.1002/jlac.18882470208
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