Knoop-Oesterlin amino acid synthesis

What is Knoop-Oesterlin amino acid synthesis?

The Knoop-Oesterlin amino acid synthesis is a chemical process used to prepare α-amino acids. This is achieved through the catalytic hydrogenation of α-oxo acids in an aqueous ammonia solution using either platinum, palladium, or Raney nickel catalysts. It is believed that Knoop-Oesterlin amino acid synthesis takes place through the formation of an unstable iminocarboxylate ion intermediate.

Knoop-Oesterlin amino acid synthesis - general reaction scheme
Knoop-Oesterlin amino acid synthesis

References

Knoop, F. and Oesterlin, Hubt. “Über die natürliche Synthese der Aminosäuren und ihre experimentelle Reproduktion.” [On the natural synthesis of amino acids and their experimental reproduction.Z. Physiol. Chem., vol. 148, no. 3-6, 1925, pp. 294-315. https://doi.org/10.1515/bchm2.1925.148.3-6.294

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