Knorr quinoline synthesis

What is Knorr quinoline synthesis?

The Knorr quinoline synthesis is a chemical reaction that results in the formation of α-hydroxyquinolines from arylamines and β-ketoesters, which are heated to a temperature exceeding 100 °C. In this process, an intermediate anilide is formed, which then undergoes cyclization through dehydration, facilitated by the addition of concentrated sulfuric acid, H2SO4.

Knorr quinoline synthesis - general reaction scheme
Knorr quinoline synthesis

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