Mandelic acid synthesis

What is mandelic acid synthesis?

Mandelic acid, also known as α-hydroxyl phenyl acetic acid, and its derivatives have proved to be highly valuable in medicinal chemistry.

Some of these derivatives have even been used in pharmaceutical applications. Over time, various methods have been developed for the mandelic acid synthesis, including methods for obtaining optically pure mandelic acid.

Mandelic acid synthesis - general reaction scheme - α-hydroxyl phenyl acetic acid
Mandelic acid synthesis

One commonly used method for preparing mandelic acid involves the use of benzaldehyde and sodium cyanide NaCN.