Mukaiyama RedOx hydration

What is Mukaiyama RedOx hydration?

The Mukaiyama RedOx hydration is an organic chemical reaction in which an alkene is hydrated to an alcohol through the action of a reagent that can provide oxygen, such as hydrogen peroxide, and a transition metal catalyst, such as palladium or ruthenium. The reaction was discovered by the Japanese chemist Teruaki Mukaiyama in the 1970s and is named after him..

Mukaiyama RedOx hydration typically proceeds through an intermediate called an “oxonium ion,” which is a three-membered ring compound that is formed when the alkene reacts with the reagent and the transition metal catalyst. The intermediate can then be hydrolyzed to produce the final alcohol product..

One of the key features of the Mukaiyama RedOx hydration is that it allows for the synthesis of alcohols from alkenes, which can be useful for synthesizing a wide range of compounds for various applications. Alcohols are also important intermediates in a number of chemical reactions and can serve as starting materials for the synthesis of other compounds..

Mukaiyama RedOx hydration can be performed under a variety of conditions, including both acidic and basic conditions. The choice of conditions depends on the specific reactants and desired product, and can be influenced by factors such as the stability of the intermediate and the ability to control the regiochemistry of the reaction..

Summary

Mukaiyama RedOx hydration is a useful tool for synthesizing alcohols and has a wide range of applications in the field of organic chemistry..

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