Nef synthesis

What is Nef synthesis?

The Nef synthesis is a chemical process that involves the addition of sodium acetylides to aldehydes and ketones, resulting in the production of acetylenic carbinols. It is important not to mistake Nef synthesis with the Nef reaction.

Nef Synthesis
Nef synthesis


  • Nef, J.V. (1899), Ueber das Phenylacetylen, seine Salze und seine Halogensubstitutionsproducte. [On phenylacetylene, its salts and its halogen substitution products.] Justus Liebigs Ann. Chem., 308: 264-328.