Normant reagent

What is Normant reagent?

The Normant reagent, which can be RCuMgBr2 or RMgBr + CuBr, is a type of mixed-metal Grignard reagent. It reacts with terminal alkynes to produce alkenylcopper compounds that are highly reactive nucleophiles, making them useful for tandem reactions like oxidations.

Normant reagent - general reaction scheme
Normant reagent

At one time, vinylmagnesium bromide (CH2=CHMgBr) was also known as the Normant reagent.


  • H. Normant, Compt. Rend. 240, 214 (1955)
  • H. Normant, Bull. Soc. Chim. France 1957, 728
  • H. Normant in Advances in Organic Chemistry vol. 11, p 1 (New York, 1960)