Pellizzari reaction

What is Pellizzari reaction?

The Pellizzari reaction involves the condensation of amides and acyl hydrazines to form substituted 1,2,4-triazoles. If the amide and acylhydrazine have different acyl groups, there is a possibility of acyl group interchange leading to the formation of a mixture of triazoles.

Pellizzari reaction - substituted 1,2,4-triazoles
Pellizzari reaction


Pellizzari, G. Nuova sintesi del triazolo e dei suoi derivati. Gazz. Chim. Ital. 1894, 24, 222–229.