Petrenko-Kritschenko piperidone synthesis

What is Petrenko-Kritschenko piperidone synthesis?

The Petrenko-Kritschenko piperidone synthesis is a double Mannich reaction that involves the preparation of piperidone from acetonedicarboxylic ester, two equivalents of aldehyde, and ammonia (or a primary amine).

Petrenko-Kritschenko piperidone synthesis - general reaction scheme
Petrenko-Kritschenko piperidone synthesis

Petrenko-Kritschenko piperidone synthesis was first reported by Petrenko-Kritschenko in 1906 and is typically carried out by refluxing the mixture of reaction components in an aqueous or alcoholic solution. However, the resulting product is difficult to purify. To address this issue, it has been found that adding acid to the reaction medium is useful.

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