Pictet-Gams isoquinoline synthesis

What is Pictet-Gams isoquinoline synthesis?

The Pictet-Gams isoquinoline synthesis involves the cyclization of acylated aminomethyl phenyl carbinols or their ethers with phosphorus pentoxide, P2O5, in toluene or xylene to form isoquinolines.

Pictet-Gams isoquinoline synthesis

References

Pictet, A. and Gams, A. (1910), Über eine neue Methode zur synthetischen Darstellung der Isochinolinbasen. [On a new method for the synthetic preparation of isoquinoline bases.] Ber. Dtsch. Chem. Ges., 43: 2384-2391. https://doi.org/10.1002/cber.191004302206

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