Pictet-Spengler isoquinoline synthesis

What is Pictet-Spengler isoquinoline synthesis?

The Pictet-Spengler isoquinoline synthesis involves the condensation of carbonyl compounds with β-arylethylamines, followed by cyclization of the resulting Schiff bases to form tetrahydroisoquinoline derivatives.

Pictet-Spengler isoquinoline synthesis

References

Pictet, A. and Spengler, T. (1911), Über die Bildung von Isochinolin-derivaten durch Einwirkung von Methylal auf Phenyl-äthylamin, Phenyl-alanin und Tyrosin. [On the formation of isoquinoline derivatives by the action of methylal on phenyl-ethylamine, phenyl-alanine and tyrosine.] Ber. Dtsch. Chem. Ges., 44: 2030-2036. https://doi.org/10.1002/cber.19110440309

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