Piloty alloxazine synthesis

What is Piloty alloxazine synthesis?

The Piloty alloxazine synthesis involves the formation of an 8-aminobenzo[g]pteridine-2,4-(1H,3H)-dione through a ring-closure reaction between 5-(hydroxyimino)pyrimidine-2,4,6-(1H,3H,5H)trione, in a boiling aqueous NaOH, and benzene-1,3-diamine.

Piloty alloxazine synthesis - boiling aqueous NaOH
Piloty alloxazine synthesis


Piloty, O. (1904), Ueber die Harnsäuregruppe. I. Ueber die Constitution des Murexids und einiger nahestehender Harnsäurederivate. [On the uric acid group. I. On the constitution of murexide and some related uric acid derivatives.] Justus Liebigs Ann. Chem., 333: 22-71. https://doi.org/10.1002/jlac.19043330103