Reissert indole synthesis

What is Reissert indole synthesis?

The Reissert indole synthesis is a reaction that involves the condensation of o-nitrotoluene with oxalic ester, followed by reduction to the amine, and cyclization to form the indole molecule.

Reissert indole synthesis


Reissert, A. (1897), Einwirkung von Oxalester und Natriumäthylat auf Nitrotoluole. Synthese nitrirter Phenylbrenztraubensäuren. [Effect of oxalate ester and sodium ethylate on nitrotoluenes. Synthesis of nitrated phenylpyruvic acids.] Ber. Dtsch. Chem. Ges., 30: 1030-1053.