Ruzicka large-ring synthesis

What is Ruzicka large-ring synthesis?

The Ruzicka large-ring synthesis is a chemical method for synthesizing large-ring alicyclic ketones. This reaction involves the thermal decomposition of metal salts of dicarboxylic acids using metals from the second and fourth groups of the periodic table, such as calcium, thorium, and cerium.

Ruzicka large-ring synthesis
Ruzicka large-ring synthesis

References

  • Ruzicka, L., Stoll, M. and Schinz, H. (1926), Zur Kenntnis des Kohlenstoffringes II. Synthese der carbocyclischen Ketone vom Zehner- bis zum Achtzehnerring. [On the knowledge of the carbon ring II. Synthesis of the carbocyclic ketones from the ten- to the eighteen-membered ring.] Helvetica Chimica Acta, 9: 249-264. https://doi.org/10.1002/hlca.19260090130
  • Ruzicka, L. and Brugger, W. (1926), Zur Kenntnis des Kohlenstoffringes III. Über die Gewinnung des Cyclo-octanons aus Azelainsäure. [On the knowledge of the carbon ring III. On the recovery of cyclo-octanone from azelaic acid.] Helvetica Chimica Acta, 9: 339-354. https://doi.org/10.1002/hlca.19260090140
  • Ruzicka, L. and Brugger, W. (1926), Zur Kenntnis des Kohlenstoffringes IV. Über die Gewinnung des Cyclo-nonanons aus Sebacinsäure. [On the knowledge of the carbon ring IV. On the recovery of cyclo-nonanone from sebacic acid.] Helvetica Chimica Acta, 9: 389-398. https://doi.org/10.1002/hlca.19260090148
  • Ruzicka, L., Brugger, W., Pfeiffer, M., Schinz, H. and Stoll, M. (1926), Zur Kenntnis des Kohlenstoffringes VI. Über die relative Bildungsleichtigkeit, die relative Beständigkeit und den räumlichen Bau der gesättigten Kohlenstoffringe. [On the knowledge of the carbon ring VI. On the relative ease of formation, the relative permanence and the spatial structure of the saturated carbon rings.] Helvetica Chimica Acta, 9: 499-520. https://doi.org/10.1002/hlca.19260090164
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