Sandmeyer isonitrosoacetanilide isatin synthesis

What is Sandmeyer isonitrosoacetanilide isatin synthesis?

The Sandmeyer isonitrosoacetanilide isatin synthesis is a process used to create isatin. This involves condensing chloral hydrate, hydroxylamine, and aniline to form isonitrosoacetodiphenylamidine. The next step is to cyclize this compound using concentrated sulfuric acid, followed by quantitative hydrolysis to yield isatin on dilution.

Sandmeyer isonitrosoacetanilide isatin synthesis - general reaction scheme
Sandmeyer isonitrosoacetanilide isatin synthesis

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