Sharpless dihydroxylation

What is Sharpless dihydroxylation?

The Sharpless dihydroxylation, also known as the Sharpless asymmetric dihydroxylation, refers to a chemical process that involves the osmium-catalyzed asymmetric cis-dihydroxylation of olefins. Scharpless was Nobel Prize in Chemistry 2022.

Sharpless dihydroxylation - Sharpless asymmetric dihydroxylation
Sharpless dihydroxylation


Asymmetric dihydroxylation via ligand-accelerated catalysis
Eric N. Jacobsen, Istvan. Marko, William S. Mungall, Georg. Schroeder, and K. Barry. Sharpless
Journal of the American Chemical Society 1988 110 (6), 1968-1970
DOI: 10.1021/ja00214a053