Sharpless epoxidation

What is Sharpless epoxidation?

The Sharpless epoxidation is a chemical reaction that involves the titanium-catalyzed asymmetric epoxidation of allylic alcohols, using a combination of titanium alkoxide, an optically active tartrate ester, and an alkyl hydroperoxide. This process allows for a high degree of enantiomeric purity, with predictable absolute stereochemistry. Sharpless was Nobel Prize in Chemistry 2022.

Sharpless epoxidation
Sharpless epoxidation

References

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