Skraup-Doebner-von Miller quinoline synthesis

What is Skraup-Doebner-von Miller quinoline synthesis?

The Skraup-Doebner-von Miller quinoline synthesis, also referred to as the Skraup-Doebner-von Miller reaction or the Doebner-Miller reaction, or Doebner-Miller synthesis or Doebner-von Miller quinoline synthesis, is a chemical process that involves the acid-catalyzed synthesis of quinolines. This is achieved by combining primary aromatic amines with α,β-unsaturated carbonyl compounds. When the α,β-unsaturated carbonyl compounds are generated in situ from either two molecules of aldehyde or from an aldehyde and a methyl ketone, the process is commonly referred to as the Beyer method for quinolines.

Skraup-Doebner-von Miller quinoline synthesis - Beyer method quinoline - Skraup-Doebner-von Miller reaction - Doebner-Miller reaction
Skraup-Doebner-von Miller quinoline synthesis

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