Staedel-Rugheimer pyrazine synthesis

What is Staedel-Rugheimer pyrazine synthesis?

The Staedel-Rugheimer pyrazine synthesis involves the reaction between α-halogenketones and ammonia, resulting in the formation of pyrazine.

Staedel-Rugheimer pyrazine synthesis
Staedel-Rugheimer pyrazine synthesis

References

Staedel, W. and Rügheimer, L. (1876), Ueber die Einwirkung von Ammoniak auf Chloracetylbenzol. [On the effect of ammonia on chloroacetylbenzene.] Ber. Dtsch. Chem. Ges., 9: 563-564. https://doi.org/10.1002/cber.187600901174

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