Urech hydantoin synthesis

What is Urech hydantoin synthesis?

The Urech hydantoin synthesis is a method for creating hydantoins from α-amino acids. It involves treating the α-amino acids with potassium cyanate in an aqueous solution, and then heating the resulting intermediate hydantoic acid salt with 25% hydrochloric acid HCl.

Urech hydantoin synthesis - general reaction scheme
Urech hydantoin synthesis


Urech, F. (1873), XXI. Ueber Lacturaminsäure und Lactylharnstoff. [On lacturamic acid and lactylurea] Justus Liebigs Ann. Chem., 165: 99-103. https://doi.org/10.1002/jlac.18731650110