Microscale – Removal of small amounts of solvents

Written by J.A Dobado | Last Updated on April 22, 2024

What is microscale removal of small amounts of solvents?

The usual way to remove a solvent is with a rotary evaporator. A solvent can be removed under reduced pressure using round-bottom flask with ground-glass joints of a suitable volume (e.g. 5 ml or 10 ml). However, there are other alternatives:

microscale: removal of small amounts of solvents

  • By gas stream. The vessel is heated in a water bath and the solvent is forced to evaporate by means of a gas stream. It is advisable to use an inert gas such as nitrogen, since the oxygen in the air can oxidize many compounds. This operation should be carried out in a fume hood to avoid accumulation of hazardous or harmful vapors in the workplace.
  • By application of vacuum. In the Figure, different options for removing a solvent under vacuum on a small scale are shown.


Back to the basic operations and specific microscale techniques page.