Meth-Cohn quinoline synthesis

What is Meth-Cohn quinoline synthesis? The Meth-Cohn quinoline synthesis entails treating acylanilides with Vilsmeier’s reagent ([(CH3)2NCHCl]Cl) in phosphorus oxychloride (POCl3) solvent under warm conditions, leading to the formation of 2-chloro-3-substituted quinolines. The Vilsmeier-Haack reaction is a widely used method for the formylation of diverse electron-rich substrates, including aliphatic, aromatic, and heteroaromatic compounds. Although it is primarily … Read more

Craig tube

What is a Craig tube? The Craig tube is a small-scale apparatus utilized in preparative and analytical chemistry for recrystallization of quantities up to 100 mg (microscale). It comprises two parts – a test tube resembling a test tube with rough ground glass in the neck and a plunger typically made of Teflon or glass. … Read more

Synthesis of 1,3-diphenyl-2-propen-1-one (chalcone)

Objective To obtain chalcone using the Claisen-Schmidt condensation by condensing an aromatic aldehyde with a ketone in the presence of a base. Background The Claisen-Schmidt condensation is a type of aldol condensation that involves synthesizing α,β-unsaturated ketones by condensing a ketone with an aromatic aldehyde. This reaction is possible because the aromatic aldehyde lacks hydrogens in … Read more

Acetophenone oxime preparation

Objective to obtain and characterize an oxime (acetophenone oxime) by reacting acetophenone with hydroxylamine hydrochloride in the presence of sodium acetate and ethanol. Background Oximes are organic compounds that contain the functional group -C=N-OH. They are synthesized by the reaction of a carbonyl compound (>C=O) with hydroxylamine NH2OH or its derivatives. The resulting product is … Read more

Preparation of methyl diantilis from ethylvanillin using solid-phase peptide synthesis (SPPS) techniques

Objective To synthesize methyl diantilis using Merrifield, polymer-supported reagents from ethylvanillin. The use of polymer-supported reagents allows for efficient and convenient reactions with minimal by-products, which makes it an attractive option for organic synthesis. Background The preparation of methyl diantilis from ethylvanillin using Merrifield, polymer-supported reagents is a laboratory experiment that utilizes solid-phase peptide synthesis … Read more

Reduction of benzophenone into diphenylmethanol with NaBH4

Objective The goal of this experiment is the the reduction of the aromatic ketone benzophenone to diphenylmethanol (benzhydrol) using sodium borohydride, NaBH4, as a reducing agent. Background The reduction of carbonyl groups is a fundamental reaction in organic chemistry. One commonly used reducing agent for this purpose is sodium borohydride (NaBH4), which is a mild … Read more

Fun chemistry experiments

What is fun chemistry experiments? Chemistry is a fascinating subject that can provide some of the most exciting and fun experiments. Whether you are a student or simply an enthusiast, conducting chemistry experiments can be a thrilling and educational experience. Here are some fun chemistry experiments that can be easily performed at home or in … Read more

Blue bottle experiment

Objective To demonstrate chemical kinetics and the concept of oxidation-reduction reactions to students. It aims to show the complex series of intermediate reactions that occur in multiple steps during the process of glucose oxidation by sodium hydroxide and atmospheric oxygen, resulting in the formation of a blue-colored solution of copper(II) ions. To provide students with … Read more

Conversion of 1-bromobutane into 1-iodobutane via SN2 mechanism (Finkelstein reaction)

Objective The objective of this experiment is to prepare 1-iodobutane by carrying out the Finkelstein reaction on 1-bromobutane, and to carried out a reaction with SN2 mechanism. Background Alkyl iodides can be synthesized through nucleophilic substitution of the corresponding bromides using a solution of sodium iodide in acetone. This reaction follows an SN2 mechanism, and … Read more

Reduction of 4-t-butylcyclohexanone with sodium borohydride (NaBH4)

Objective The objective of this experiment is to provide familiarity with a reduction reaction using sodium borohydride (NaBH4) as the reducing agent. The experiment will utilize 4-t-butylcyclohexanone as the starting material for the reaction. Background Unsymmetrical ketones can be converted to sp3 secondary alcohols by reducing the sp2 carbonyl group. This reaction creates a new … Read more