Written by J.A Dobado | Last Updated on September 15, 2025
What is Meisenheimer rearrangements?
The Meisenheimer rearrangements refer to the process where O,N,N-trisubstituted hydroxylamines are produced from tertiary amine oxides through [1,2]-R group migration, or [2,3]-sigmatropic rearrangement if R’ is an allyl group (see list of acronyms).
References
- Meisenheimer, J. (1919), Über eine eigenartige Umlagerung des Methyl-allyl-anilin-N-oxyds. [On a peculiar rearrangement of the methyl allyl aniline N-oxide.] Ber. Dtsch. Chem. Ges. A/B, 52: 1667-1677. https://doi.org/10.1002/cber.19190520830
Full Professor of Organic Chemistry at the University of Granada, with a long-standing research career in Computational Chemistry and molecular modeling and design.