Passerini reaction

What is Passerini reaction?

The Passerini reaction is a chemical reaction that involves the creation of α-hydroxycarboxamides through the treatment of an isonitrile with a carboxylic acid and an aldehyde or ketone.

Passerini reaction
Passerini reaction


  • M. Passerini, “Isonitriles. I. Compound of p-isonitrileazobenzene with acetone and acetic acid” Gazz. Chim. Ital. 51, 126-129 (1921)
  • M. Passerini, “Isonitriles. II. Compounds with aldehydes or with ketones and monobasic organic acids.” Gazz. Chim. Ital. 51, 181-188 (1921)
  • M. Passerini, “The isonitriles. VI. Reaction with cyclic ketones in the presence of organic acids” Gazz. Chim. Ital. 53, 410-417 (1923)
  • M. Passerini, Gazz. Chim. Ital. 54, 529 (1924)