Wohl degradation

What is Wohl degradation?

The Wohl degradation is a chemical process used to convert an aldose into an aldose with one fewer carbon atoms, achieved through the reversal of the cyanohydrin synthesis. In this method, the nitrile group is eliminated through treatment with ammoniacal silver oxide. Another variation of this reaction, known as the Zemplén modification, involves the use of sodium alkoxide in the nitrile elimination process.

Wohl degradation - general reaction scheme - Zemplén modification uses sodium alkoxide
Wohl degradation