Written by J.A Dobado | Last Updated on September 15, 2025
What is Bradsher cycloaddition?
The Bradsher cycloaddition involves a [4+2] cycloaddition reaction that occurs between a commonly used dienophile and cationic aromatic azadienes such as acridizinium or isoquinolinium.
References
C.K. Bradsher, T.W.G. Solomons, “Acridizinium Ion Chemistry. II. The Diels-Alder Reaction”
Journal of the American Chemical Society 1958 80 (4), 933-934
DOI: 10.1021/ja01537a045
Full Professor of Organic Chemistry at the University of Granada, with a long-standing research career in Computational Chemistry and molecular modeling and design.