What is Heck reaction?
The Heck reaction refers to a stereospecific palladium-catalyzed coupling process that involves the reaction of alkenes with organic halides or triflates lacking sp3-hybridized β-hydrogens.
- R4 = aryl, alkenyl, benzyl
- X = I, Br, OSO2CF3
- L = PAr3, DPP, BINAP (see acronyms)
- base = NEt3, K2CO3, NaOCOCH3
References
R.F. Heck, J.P. Nolley, Jr., “Palladium-catalyzed vinylic hydrogen substitution reactions with aryl, benzyl, and styryl halides” The Journal of Organic Chemistry 37, 2320-2322 (1972)
Full Professor of Organic Chemistry at the University of Granada, with a long-standing research career in Computational Chemistry and molecular modeling and design.